Iron(III) triflate-catalyzed one-pot synthesis of acetal-type protected cyanohydrins from carbonyl compounds

被引:23
作者
Iwanami, Katsuyuki [1 ]
Aoyagi, Masaru [1 ]
Oriyama, Takeshi [1 ]
机构
[1] Ibaraki Univ, Fac Sci, Mito, Ibaraki 3108512, Japan
关键词
iron(III) triflate; cyanation; cyanohydrin THP ether; acetal-type protective group; trimethylsilyl cyanide; carbonyl compounds;
D O I
10.1016/j.tetlet.2006.04.106
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A variety of cyanohydrin THP ethers were readily prepared from carbonyl compounds with trimethylsilyl cyanide and tetrahydropyran-2-yl acetate under the influence of a catalytic amount of iron(III) triflate in a convenient one-pot procedure. This method was also effective to prepare O-protected cyanohydrins by various acetal-type protective groups. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4741 / 4744
页数:4
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