Cytotoxic cyclolignans related to podophyllotoxin

被引：23

作者：

Gordaliza, M ^{[1
]}

del Corral, JMM ^{[1
]}

Castro, MA ^{[1
]}

García-García, PA ^{[1
]}

San Feliciano, A ^{[1
]}

机构：

[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain

来源：

FARMACO | 2001年 / 56卷 / 04期

关键词：

cyclolignans; podophyllotoxin; pyrazoline; cytotoxic; antineoplastic; immunosuppressive;

D O I：

10.1016/S0014-827X(01)01030-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cyclolignan family of natural products includes compounds with important antineoplastic and antiviral properties such as podophyllotoxin and two of their semisynthetic derivatives, etoposide and teniposide. The latter are included in a wide variety of cancer chemotherapy protocols. Due to these biological activities, cyclolignans have been the objective of numerous studies focused to prepare better and safer anticancer drugs. Several cyclolignans related to podophyllotoxin have, been prepared and evaluated for their cytotoxic activities on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28); some of them have antiviral and immunosuppressive activities. (C) 2001 Elsevier Science S.A. All rights reserved.

引用

页码：297 / 304

页数：8

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