Copper-Mediated Coupling of 1,1-Dibromo-1-alkenes with Nitrogen Nucleophiles: A General Method for the Synthesis of Ynamides

被引：204

作者：

Coste, Alexis ^{[1
]}

Karthikeyan, Ganesan ^{[1
]}

Couty, Francois ^{[1
]}

Evano, Gwilherm ^{[1
]}

机构：

[1] Univ Versailles St Quentin Yvelines, Inst Lavoisier Versailles, CNRS, UMR 8180, F-78035 Versailles, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 24期

关键词：

copper; cross-coupling; dibromoalkenes; homogeneous catalysis; ynamides; RING-CLOSING METATHESIS; N-FUNCTIONALIZED; 1-ALKYNYLAMIDES; AXIALLY CHIRAL ANILIDES; INTRAMOLECULAR AMIDATION; CATALYZED CYCLIZATION; ALKYNYL BROMIDES; DERIVATIVES; 1,6-DIYNES; CYCLOADDITIONS; CHEMISTRY;

D O I：

10.1002/anie.200901099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mild reaction conditions are the advantage of the title reaction, which allows straightforward entry to a variety of ynamides starting from readily available 1,1-dibromo-1- alkenes, which act as attractive alkynylating agents (see scheme; EWG=electron-withdrawing group, DMF=N,Ndimethylformamide). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4381 / 4385

页数：5

共 75 条

[71] Copper salt-catalyzed azide-[3+2] cycloadditions of ynamides and bis-ynamides [J].