Novel noncryogenic InAsSb photovoltaic detectors grown by molecular beam epitaxy are proposed and demonstrated. The quaternary alloy In0.88Al0.12As0.80Sb0.20 is introduced as a wide bandgap barrier layer lattice matched to the GaSb substrate. The valence band edge of In0.88Al0.12As0.80Sb0.20 nearly matches with InAs0.91Sb0.09, leading to more efficient transport of photogenerated holes. The resulting mid-infrared photovoltaic detector exhibits a 50% cutoff wavelength of 4.31 mu m and a peak responsivity of 0.84 A/W at room temperature. High Johnson-noise-limited detectivity (D*) of 2.6 x 10(9) cm (.) Hz(1/2)/W at 4.0 mu m, and 4.2 x 10(10) cm (.) Hz(1/2)/W at 3.7 mu m are achieved at 300 K and 230 K, respectively.