Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

被引：43

作者：

Banchereau, Romain ^{[1
]}

Baldwin, Nicole ^{[1
]}

Cepika, Alma-Martina ^{[1
]}

Athale, Shruti ^{[1
]}

Xue, Yaming ^{[1
]}

Yu, Chun I. ^{[1
]}

Metang, Patrick ^{[1
]}

Cheruku, Abhilasha ^{[1
]}

Berthier, Isabelle ^{[1
]}

Gayet, Ingrid ^{[1
]}

Wang, Yuanyuan ^{[1
]}

Ohouo, Marina ^{[1
]}

Snipes, LuAnn ^{[1
]}

Xu, Hui ^{[1
]}

Obermoser, Gerlinde ^{[1
]}

Blankenship, Derek ^{[1
]}

Oh, Sangkon ^{[1
]}

Ramilo, Octavio ^{[2
]}

Chaussabel, Damien ^{[3
,4
]}

Banchereau, Jacques ^{[1
,5
]}

Palucka, Karolina ^{[1
,5
]}

Pascual, Virginia ^{[1
]}

机构：

[1] Baylor Inst Immunol Res, Dallas, TX 75204 USA

[2] Nationwide Childrens Hosp, Columbus, OH 43205 USA

[3] Benaroya Res Inst, Seattle, WA 98101 USA

[4] Sidra Med & Res Ctr, Doha, Qatar

[5] Jackson Lab Genom Med, Farmington, CT 06030 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家卫生研究院;

关键词：

JUVENILE IDIOPATHIC ARTHRITIS; YELLOW-FEVER VACCINE; SYSTEMS BIOLOGY; GENE-EXPRESSION; IFN-ALPHA; T-CELLS; RECEPTORS; INFLUENZA; IMMUNITY; INFLAMMASOME;

D O I：

10.1038/ncomms6283

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The mechanisms by which microbial vaccines interact with human APCs remain elusive. Herein, we describe the transcriptional programs induced in human DCs by pathogens, innate receptor ligands and vaccines. Exposure of DCs to influenza, Salmonella enterica and Staphylococcus aureus allows us to build a modular framework containing 204 transcript clusters. We use this framework to characterize the responses of human monocytes, monocyte-derived DCs and blood DC subsets to 13 vaccines. Different vaccines induce distinct transcriptional programs based on pathogen type, adjuvant formulation and APC targeted. Fluzone, Pneumovax and Gardasil, respectively, activate monocyte-derived DCs, monocytes and CD1c + blood DCs, highlighting APC specialization in response to vaccines. Finally, the blood signatures from individuals vaccinated with Fluzone or infected with influenza reveal a signature of adaptive immunity activation following vaccination and symptomatic infections, but not asymptomatic infections. These data, offered with a web interface, may guide the development of improved vaccines.

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