Interactions of a Tetraanionic Porphyrin with DNA: from a Z-DNA Sensor to a Versatile Supramolecular Device

被引：110

作者：

D'Urso, Alessandro ^{[2
]}

Mammana, Angela ^{[2
]}

Balaz, Milan ^{[5
]}

Holmes, Andrea E. ^{[4
]}

Berova, Nina ^{[3
]}

Lauceri, Rosaria ^{[1
]}

Purrello, Roberto ^{[2
]}

机构：

[1] CNR, Ist Biostrutture & Bioimmagini, Sez Catania, I-95125 Catania, Italy

[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

[3] Columbia Univ, Dept Chem, New York, NY 10027 USA

[4] Doane Coll, Dept Chem, Crete, NE 68333 USA

[5] Univ Wyoming, Dept Chem, Laramie, WY 82071 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 06期

基金：

美国国家科学基金会;

关键词：

B-DNA; CIRCULAR-DICHROISM; TRANSITION; BINDING; THERMODYNAMICS; COMPLEXES; ADENOSINE; ADAR1;

D O I：

10.1021/ja808099u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The anionic nickel(II) porphyrin NiTPPS is able to selectively sense the spermine induced left-handed Z-form of DNA while it is completely silent in the presence of right-handed B-DNA. Interactions between the DNA and the porphyrin can be easily modulated by pH and temperature. The resulting Z-DNA-porphyrin-spermine complex behaves as a supramolecular reversible information storage system and as a reversible AND logic gate.

引用

页码：2046 / +

页数：4

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