Catalysis of phosphodiester transesterification by Cu(II)-terpyridine complexes with peripheral pendent base groups: Implications for the mechanism

被引:44
作者
Liu, SH [1 ]
Hamilton, AD [1 ]
机构
[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260
关键词
D O I
10.1016/S0040-4039(96)02519-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
In this paper we show that in phosphodiester transesterification catalyzed by copper(II)-terpyridine complexes both the metal-bound hydroxyl group and the peripheral pendent tertiary amino groups can provide general base catalysis. At neutral pH the pendent amino groups dominate the process because the metal-bound hydroxyl group is protonated. However, the metal-bound hydroxyl group is more effective at high pH, probably due to its higher basicity and/or closer location to the bound substrate. (C) 1997, Elsevier Science Ltd.
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页码:1107 / 1110
页数:4
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