Antimutagenic activity of casein against MNNG in the E-coli DNA repair host-mediated assay

被引：10

作者：

vanBoekel, MAJS ^{[1
]}

Goeptar, AR ^{[1
]}

Alink, GM ^{[1
]}

机构：

[1] AGR UNIV WAGENINGEN,DEPT TOXICOL,NL-6703 HE WAGENINGEN,NETHERLANDS

来源：

CANCER LETTERS | 1997年 / 114卷 / 1-2期

关键词：

casein; antimutagenicity; soy protein; MNNG; host-mediated assay;

D O I：

10.1016/S0304-3835(97)04630-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of caseinate and soy protein in the diet on the mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was assessed in-vivo and ex-vivo in the DNA-repair host-mediated assay and liquid suspension assay, respectively. Of the two proteins only casein showed a strong antimutagenic activity over the whole digestive tract, except in the stomach. It is suggested that the molecular structure of a protein determines its protective effect against mutagens: casein lacks secondary and tertiary structure so that amino acids are more readily available for interaction with the mutagen than with the amino acids in soy protein which is a globular protein. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：85 / 87

页数：3

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