Proline-catalyzed direct asymmetric aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones

被引：31

作者：

Funabiki, Kazumasa ^{[1
]}

Yamamoto, Hitoshi ^{[1
]}

Nagaya, Hideyuki ^{[1
]}

Matsui, Masaki ^{[1
]}

机构：

[1] Gifu Univ, Fac Engn, Dept Mat Sci & Technol, Gifu 5011193, Japan

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 31期

关键词：

fluorine and compounds; aldol reactions; amino acids and derivatives; asymmetric reactions;

D O I：

10.1016/j.tetlet.2006.05.165

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

L-Proline-catalyzed direct asymmetric aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with unmodified ketones smoothly occurred at ambient temperature to produce beta-hydroxy-beta-trifluoromethylated ketones with good to excellent diastereo (up to 96% de) and enantioselectivities (up to 91% ee). (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：5507 / 5510

页数：4

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