Novel biocatalytic reduction of aryl azides: Chemoenzymatic synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics

被引：51

作者：

Kamal, A

Damayanthi, Y

Reddy, BSN

Lakminarayana, B

Reddy, BSP

机构：

[1] Indian Inst. of Chemical Technology

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 11期

关键词：

D O I：

10.1039/a701249g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chemoselective reduction of aryl azides to aryl amines, and the synthesis of the imine-containing pyrrolo[2,1-c]-[1,4]benzodiazepine DNA-binding antitumour antibiotics by selective biocatalytic reductive cyclization of azido aldehydes, has been achieved by employing baker's yeast.

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页码：1015 / 1016

页数：2

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