Highly enantioselective copper-catalyzed conjugate addition of diethylzinc to nitroalkenes

被引：59

作者：

Choi, H ^{[1
]}

Hua, ZH ^{[1
]}

Ojima, I ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 16期

关键词：

D O I：

10.1021/ol0491282

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed asymmetric conjugate addition of diethylzinc to nitroalkenes using new chiral monodentate phosphoramidite ligands proceeds with high enantioselectivity up to 99% ee.

引用

页码：2689 / 2691

页数：3

共 16 条

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[5] ALEXAKIS A, 1994, ORGANOCOPPER REAGENT, P159
[6] Highly enantioselective conjugate addition of dialkylzinc reagents to acyclic nitroalkenes:: A catalytic route to β2-amino acids, aldehydes, and alcohols
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[7] One-pot multi-substrate enantioselective conjugate addition of diethylzinc to nitroalkenes
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[8] Phosphoramidites: Marvellous ligands in catalytic asymmetric conjugate addition
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[9] New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations
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[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (15) : 5411 - 5416
[10] Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation
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[J]. ORGANIC LETTERS, 2003, 5 (21) : 3831 - 3834

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