Highly Efficient Synthesis of trans-β,γ-Unsaturated α-Keto Amides

被引：25

作者：

Allais, Christophe ^{[1
]}

Constantieux, Thierry ^{[1
]}

Rodriguez, Jean ^{[1
]}

机构：

[1] Aix Marseille Univ, Inst Sci Mol Marseille, CNRS, UMR 6263,iSm2, F-13397 Marseille 20, France

来源：

SYNTHESIS-STUTTGART | 2009年 / 15期

关键词：

beta; gamma-unsaturated alpha-keto amide; alpha-keto acid; amine; peptidic coupling; Michael acceptor; DIELS-ALDER REACTIONS; AMINO-ACID DERIVATIVES; ONE-POT SYNTHESIS; MICHAEL ADDITION; RAPID SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; MULTICOMPONENT REACTIONS; DOUBLE-CARBONYLATION; PROTEASE INHIBITORS; AEROBIC OXIDATION;

D O I：

10.1055/s-0029-1216869

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient, metal-free, and selective access to trans-beta,gamma-unsaturated alpha-keto amides is described via peptidic coupling, involving easy to prepare trans-beta,gamma-unsaturated alpha-keto acids and commercially available amines.

引用

页码：2523 / 2530

页数：8

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