The Preliminary Studies of Electrochemical Behavior of Paracetamol and Its Metabolites on Glassy Carbon Electrode by Voltammetric Methods

被引：22

作者：

Baranowska, Irena ^{[1
]}

Koper, Marta ^{[1
]}

机构：

[1] Silesian Tech Univ, Fac Chem, Dept Analyt & Gen Chem, PL-44100 Gliwice, Poland

来源：

ELECTROANALYSIS | 2009年 / 21卷 / 10期

关键词：

Paracetamol; Glucuronide metabolites of PAR; Sulfate metabolites of PAR; Voltammetry; ACETAMINOPHEN; URINE; PLASMA; SERUM; ASSAY;

D O I：

10.1002/elan.200804536

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The new, rapid and sensitive method for the determination of paracetamol (PAR) and its glucuronide (PG) and sulfate (PS) metabolites is proposed. The electrochemical properties of the compounds were examined by cyclic voltammetry (CV) on classy carbon electrode (GCE). All measurements were carried out in Britton-Robinson buffers (BR) with different pH values over the pH range 1.81-7.24. The preliminary research indicated that PAR could be determined simultaneously with one of its metabolites. The linearity of calibration curves was obtained for concentrations between 1.65 x 10(-5) and 1.65 x 10(-4) M for PAR, 1.53 x 10(-5) and 1.53 x 10(-4) M for PG and 2.17 x 10(-5) and 1.52 x 10(-4) M for PS.

引用

页码：1194 / 1199

页数：6

共 16 条

[1] ASSAY OF PARACETAMOL AND ITS METABOLITES IN URINE, PLASMA AND SALIVA OF CHILDREN WITH CHRONIC LIVER-DISEASE [J].

ALOBAIDY, SS ;

PO, ALW ;

MCKIERNAN, PJ ;

GLASGOW, JFT ;

MILLERSHIP, J .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (08) :1033-1039

[2]

Bard A.J., 2001, ELECTROCHEMICAL METH

[3] Determination of the antibiotic drug pefloxacin in bulk form, tablets and human serum using square wave cathodic adsorptive stripping voltammetry [J].

Beltagi, AM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (06) :1079-1088

[4] Simple and rapid assay for acetaminophen and conjugated metabolites in low-volume serum samples [J].

Brunner, LJ ;

Bai, S .

JOURNAL OF CHROMATOGRAPHY B, 1999, 732 (02) :323-329

[5] A validated method for the determination of paracetamol and its glucuronide and sulphate metabolites in the urine of HIV+/AIDS patients using wavelength-switching UV detection [J].

Di Girolamo, A ;

O'Neill, WM ;

Wainer, IW .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 17 (6-7) :1191-1197

[6] Differential pulse voltammetric determination of paracetamol at nanogold modified indium tin oxide electrode [J].

Goyal, RN ;

Gupta, VK ;

Oyama, M ;

Bachheti, N .

ELECTROCHEMISTRY COMMUNICATIONS, 2005, 7 (08) :803-807

[7] Voltammetric determination of paracetamol at C60-modified glassy carbon electrode [J].

Goyal, RN ;

Singh, SP .

ELECTROCHIMICA ACTA, 2006, 51 (15) :3008-3012

[8] Direct determination of paracetamol and its metabolites in urine and serum by capillary electrophoresis with ultraviolet and mass spectrometric detection [J].

Heitmeier, S ;

Blaschke, G .

JOURNAL OF CHROMATOGRAPHY B, 1999, 721 (01) :93-108

[9] Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine [J].

Hewavitharana, A. K. ;

Lee, S. ;

Dawson, P. A. ;

Markovich, D. ;

Shaw, P. N. .

ANALYTICAL BIOCHEMISTRY, 2008, 374 (01) :106-111

[10] The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay [J].

Jensen, LS ;

Valentine, J ;

Milne, RW ;

Evans, AM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 34 (03) :585-593

← 1 2 →