Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

被引：116

作者：

Nay, Bastien ^{[1
]}

Riache, Nassima ^{[1
]}

Evanno, Laurent ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS, Unite Mol Commun & Adaptat Microorganismes, FRE 3206, F-75005 Paris, France

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 08期

关键词：

ASYMMETRIC TOTAL-SYNTHESIS; TYROSINE-PHOSPHATASE INHIBITOR; HUMAN NEUROBLASTOMA-CELLS; PSEUDEUROTIUM-OVALIS STOLK; ANTIFUNGAL CYCLIC-PEPTIDES; FUNGUS COROLLOSPORA-PULCHELLA; P53-TRANSFECTED CANCER-CELLS; SPONGE MICROSCLERODERMA SP; CONVERGENT TOTAL-SYNTHESIS; OXIRANYL ANION STRATEGY;

D O I：

10.1039/b903905h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural products containing non-tetramic gamma-hydroxy-gamma-lactams and gamma-alkylidene-gamma-lactams are usually but not exclusively derived from the mixed polyketide-non-ribosomal peptide biosynthetic pathway. Often they are fungal metabolites, although some plant- and marine-derived exceptions exist. Owing to their unique structures and biological properties, they have gained interest in the chemical and biological communities. In this review, we aim to emphasize the structural originality of these compounds, their biological properties and the synthetic efforts developed to reach them; 157 references are cited.

引用

页码：1044 / 1062

页数：19

共 148 条

[1] SPIROSTAPHYLOTRICHIN-U AND SPIROSTAPHYLOTRICHIN-V FROM CURVULARIA-PALLESCENS [J].