The enantioselective intramolecular aminative functionalization of unactivated alkenes, dienes, allenes and alkynes for the synthesis of chiral nitrogen heterocycles

被引：236

作者：

Chemler, Sherry R. ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 15期

基金：

美国国家卫生研究院;

关键词：

AZA-WACKER REACTIONS; ASYMMETRIC HYDROAMINATION; CATALYZED HYDROAMINATION; PALLADIUM; COMPLEXES; DIAMINATION; OLEFINS; AMINOPALLADATION; CARBOAMINATION; CYCLIZATION;

D O I：

10.1039/b907743j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective intramolecular aminative functionalization of unactivated alkenes and related pi-systems is a straight-forward and atom economical strategy for the synthesis of chiral nitrogen heterocycles. These reactions can be categorized as oxidatively neutral, such as alkene hydroamination, or as oxidative reactions, such as alkene difunctionalization, e.g. aminooxygenation and carboamination. This perspective reviews the current work in the field and explores mechanistic trends that are common among the different catalysts and reaction types.

引用

页码：3009 / 3019

页数：11

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