Dominant surface stress driven by biomolecular interactions in the dynamical response of nanomechanical microcantilevers

被引:64
作者
Hwang, Kyo Seon [1 ]
Eom, Kilho
Lee, Jeong Hoon
Chun, Dong Won
Cha, Byung Hak
Yoon, Dae Sung
Kim, Tae Song
Park, Jung Ho
机构
[1] Korea Inst Sci & Technol, Microsyst Res Ctr, Seoul 136791, South Korea
[2] Korea Univ, Dept Elect & Comp Engn, Seoul 136701, South Korea
关键词
D O I
10.1063/1.2372700
中图分类号
O59 [应用物理学];
学科分类号
摘要
Nanomechanical microcantilevers have played a vital role in detecting biomolecular interactions. The ability of microcantilevers to detect biomolecular interactions is ascribed to the principle that the surface stress, caused by biomolecular interactions, dominates the dynamical response of the microcantilever. Here we have experimentally studied the correlation between biomolecular interactions and the dynamical response of microcantilevers. Moreover, the authors employed a mechanical beam model to calculate the surface stress, representing the biomolecular interactions, through measuring the resonant frequency shift. The quantitative analysis of surface stress, driven by the specific protein-protein interactions, demonstrated that microcantilevers enable the quantitative study of biomolecular interactions. (c) 2006 American Institute of Physics.
引用
收藏
页数:3
相关论文
共 14 条
  • [1] Label-free protein assay based on a nanomechanical cantilever array
    Arntz, Y
    Seelig, JD
    Lang, HP
    Zhang, J
    Hunziker, P
    Ramseyer, JP
    Meyer, E
    Hegner, M
    Gerber, C
    [J]. NANOTECHNOLOGY, 2003, 14 (01) : 86 - 90
  • [2] Surface stress in the self-assembly of alkanethiols on gold
    Berger, R
    Delamarche, E
    Lang, HP
    Gerber, C
    Gimzewski, JK
    Meyer, E
    Guntherodt, HJ
    [J]. SCIENCE, 1997, 276 (5321) : 2021 - 2024
  • [3] Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition
    Dorignac, J
    Kalinowski, A
    Erramilli, S
    Mohanty, P
    [J]. PHYSICAL REVIEW LETTERS, 2006, 96 (18)
  • [4] Nanomechanical forces generated by surface grafted DNA
    Hagan, MF
    Majumdar, A
    Chakraborty, AK
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (39) : 10163 - 10173
  • [5] In-situ quantitative analysis of a prostate-specific antigen (PSA) using a nanomechanical PZT cantilever
    Hwang, KS
    Lee, JH
    Park, J
    Yoon, DS
    Park, JH
    Kim, TS
    [J]. LAB ON A CHIP, 2004, 4 (06) : 547 - 552
  • [6] Immunoassay of prostate-specific antigen (PSA) using resonant frequency shift of piezoelectric nanomechanical microcantilever
    Lee, JH
    Hwang, KS
    Park, J
    Yoon, KH
    Yoon, DS
    Kim, TS
    [J]. BIOSENSORS & BIOELECTRONICS, 2005, 20 (10) : 2157 - 2162
  • [7] Label free novel electrical detection using micromachined PZT monolithic thin film cantilever for the detection of C-reactive protein
    Lee, JH
    Yoon, KH
    Hwang, KS
    Park, J
    Ahn, S
    Kim, TS
    [J]. BIOSENSORS & BIOELECTRONICS, 2004, 20 (02) : 269 - 275
  • [8] Effect of mass and stress on resonant frequency shift of functionalized Pb(Zr0.52Ti0.48)O3 thin film microcantilever for the detection of C-reactive protein
    Lee, JH
    Kim, TS
    Yoon, KH
    [J]. APPLIED PHYSICS LETTERS, 2004, 84 (16) : 3187 - 3189
  • [9] ProteoChip: A highly sensitive protein microarray prepared by a novel method of protein, immobilization for application of protein-protein interaction studies
    Lee, Y
    Lee, EK
    Cho, YW
    Matsui, T
    Kang, IC
    Kim, TS
    Han, MH
    [J]. PROTEOMICS, 2003, 3 (12) : 2289 - 2304
  • [10] MIEROVITCH L, 1967, ANAL METHODS VIRBATI