Relaxivity modulation in Gd-functionalised mesoporous silicas

被引：59

作者：

Carniato, Fabio ^{[1
]}

Tei, Lorenzo ^{[2
]}

Dastru, Walter ^{[3
]}

Marchese, Leonardo ^{[1
]}

Botta, Mauro ^{[2
]}

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci & Tecnol Avanzate, Ctr Interdisciplinare Nanosistemi, I-15100 Alessandria, Italy

[2] Univ Piemonte Orientale Amedeo Avogadro, Dipartimento Sci Ambiente & Vita, I-15100 Alessandria, Italy

[3] Univ Turin, Mol Imaging Ctr, Fac Farm, I-10100 Turin, Italy

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 10期

关键词：

MRI CONTRAST AGENTS; AQUEOUS SUSPENSIONS; NANOPARTICLES; GADOLINIUM; THERAPEUTICS; LIPOSOMES; LIGANDS; SYSTEM; PROBES;

D O I：

10.1039/b820591d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two hybrid materials based on mesoporous silicas SBA-15 and MCM-41 functionalized with stable and electrically neutral Gd(III) macrocyclic complexes were prepared, and their 1 H NMR relaxometric properties investigated as a function of temperature and magnetic field strength.

引用

收藏

页码：1246 / 1248

页数：3

相关论文

共 31 条

[1] High sensitivity lanthanide(III) based probes for MR-medical imaging [J].

Aime, S. ;

Crich, S. Geninatti ;

Gianolio, E. ;

Giovenzana, G. B. ;

Tei, L. ;

Terreno, E. .

COORDINATION CHEMISTRY REVIEWS, 2006, 250 (11-12) :1562-1579

[2] Viral nanoparticles donning a paramagnetic coat: Conjugation of MRI contrast agents to the MS2 capsid [J].

Anderson, Elizabeth A. ;

Isaacman, Steven ;

Peabody, David S. ;

Wang, Edwin Y. ;

Canary, James W. ;

Kirshenbaum, Kent .

NANO LETTERS, 2006, 6 (06) :1160-1164

[3] Bifunctional ligands based on the DOTA-monoamide cage [J].

Barge, Alessandro ;

Tei, Lorenzo ;

Upadhyaya, Dharita ;

Fedeli, Franco ;

Beltrami, Lorena ;

Stefania, Rachele ;

Aime, Silvio ;

Cravotto, Giancarlo .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (07) :1176-1184

[4] Thermodynamic and structural properties of Gd(III) complexes with polyamino-polycarboxylic ligands: basic compounds for the development of MRI contrast agents [J].

Bianchi, A ;

Calabi, L ;

Corana, F ;

Fontana, S ;

Losi, P ;

Maiocchi, A ;

Paleari, L ;

Valtancoli, B .

COORDINATION CHEMISTRY REVIEWS, 2000, 204 :309-393

[5] STUDIES OF GD(III)-EXCHANGED Y-TYPE ZEOLITES RELEVANT TO MAGNETIC-RESONANCE-IMAGING [J].

BRESINSKA, I ;

BALKUS, KJ .

JOURNAL OF PHYSICAL CHEMISTRY, 1994, 98 (49) :12989-12994

[6] Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications [J].

Caravan, P ;

Ellison, JJ ;

McMurry, TJ ;

Lauffer, RB .

CHEMICAL REVIEWS, 1999, 99 (09) :2293-2352

[7]

Caruthers Shelton D, 2006, Methods Mol Med, V124, P387

[8] Recent advances in iron oxide nanocrystal technology for medical imaging [J].

Corot, Claire ;

Robert, Philippe ;

Idee, Jean-Marc ;

Port, Marc .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504

[9] High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: Nanosized MRI contrast agents [J].

Datta, Ankona ;

Hooker, Jacob M. ;

Botta, Mauro ;

Francis, Matthew B. ;

Aime, Silvio ;

Raymond, Kenneth N. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (08) :2546-2552

[10] Nanoparticle therapeutics: an emerging treatment modality for cancer [J].

Davis, Mark E. ;

Chen, Zhuo ;

Shin, Dong M. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782

← 1 2 3 4 →