From aldehydes to nitriles, a general and high yielding transformation using HOF•CH3CN complex

被引：28

作者：

Carmeli, Mira ^{[1
]}

Shefer, Neta ^{[1
]}

Rozen, Shlomo ^{[1
]}

机构：

[1] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 50期

基金：

以色列科学基金会;

关键词：

D O I：

10.1016/j.tetlet.2006.10.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N,N-Dimethylhydrazones of aldehydes undergo a rapid oxidative cleavage to form nitriles in very high yields on reaction with HOF-CH3CN under mild conditions. The reaction is chemoselective and proceeds rapidly without racemization. The nitriles were resistant to further oxidation, even when a large excess of the reagent was employed. (c) 2006 Elsevier Ltd. All rights reserved.

引用

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页码：8969 / 8972

页数：4

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