Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2

被引:14
作者
Boumghar-Bourtchai, Leyla [1 ]
Dhalluin, Anne [1 ,3 ]
Malbruny, Brigitte [1 ,2 ]
Galopin, Sebastien [1 ]
Leclercq, Roland [1 ,2 ]
机构
[1] Univ Caen, EA Interact Hote & Microorganismes Epitheliums 21, F-14032 Caen, France
[2] CHU Cote Nacre, Microbiol Serv, Caen, France
[3] Univ Caen, UFR Sci Pharmaceut, F-14032 Caen, France
关键词
RIBOSOMAL-RNA; TARGET; SITE;
D O I
10.1128/AAC.01633-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.
引用
收藏
页码:4007 / 4009
页数:3
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