Catalytic antibodies as designer proteases and esterases

被引：77

作者：

Tanaka, F ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr010180a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic... This review describes monoclonal catalytic antibodies that catalyze the hydrolysis of ester, amide, carbonate, and carbamate. Focus is on aspects of hapten design, selection strategy, and their consequences. The purpose is to provide an understanding of how designer protein catalysts are created using the immune system.

引用

页码：4885 / 4906

页数：22

共 134 条

[41] CRYSTAL-STRUCTURE OF A CATALYTIC ANTIBODY FAB WITH ESTERASE-LIKE ACTIVITY [J].

GOLINELLIPIMPANEAU, B ;

GIGANT, B ;

BIZEBARD, T ;

NAVAZA, J ;

SALUDJIAN, P ;

ZEMEL, R ;

TAWFIK, DS ;

ESHHAR, Z ;

GREEN, BS ;

KNOSSOW, M .

STRUCTURE, 1994, 2 (03) :175-183

[42] A CHROMOGENIC ASSAY FOR SCREENING LARGE ANTIBODY LIBRARIES [J].

GONG, B ;

LESLEY, SA ;

SCHULTZ, PG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (04) :1486-1487

[43] Use of antibodies to dissect the components of a catalytic event. The cyclopropenone hapten [J].

Grynszpan, F ;

Keinan, E .

CHEMICAL COMMUNICATIONS, 1998, (08) :865-866

[44]

Guo Jincan, 1994, Journal of the American Chemical Society, V116, P6062, DOI 10.1021/ja00093a002

[45] Antibody-mediated regio- and enantioselective resolution of a glycerol derivative [J].

Ikeda, K ;

Achiwa, K .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (02) :225-228

[46] ASYMMETRIC INDUCTION VIA A CATALYTIC ANTIBODY [J].

IKEDA, S ;

WEINHOUSE, MI ;

JANDA, KD ;

LERNER, RA ;

DANISHEFSKY, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (20) :7763-7764

[47] Phospholipase A2-like catalytic antibody [J].

Isomura, S ;

Ito, K ;

Haruna, M .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (04) :555-558

[48] SEQUENCE-SPECIFIC PEPTIDE CLEAVAGE CATALYZED BY AN ANTIBODY [J].

IVERSON, BL ;

LERNER, RA .

SCIENCE, 1989, 243 (4895) :1184-1188

[49] A modified bait and switch strategy for the generation of esterolytic abzymes using concerted catalytic mechanisms [J].

Iwabuchi, Y ;

Kurihara, S ;

Oda, M ;

Fujii, I .

TETRAHEDRON LETTERS, 1999, 40 (29) :5341-5344

[50] REGIOSELECTIVE AND STEREOSELECTIVE DEPROTECTION OF ACYLATED CARBOHYDRATES VIA CATALYTIC ANTIBODIES [J].

IWABUCHI, Y ;

MIYASHITA, H ;

TANIMURA, R ;

KINOSHITA, K ;

KIKUCHI, M ;

FUJII, I .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (02) :771-772

← 1 2 3 4 5 6 7 8 9 10 →