Direct Arylations of 2H-Indazoles On Water

被引：155

作者：

Ohnmacht, Stephan A. ^{[1
]}

Culshaw, Andrew J. ^{[2
]}

Greaney, Michael F. ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Novartis Horsham Res Ctr, Horsham RH12 5AB, W Sussex, England

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

CATALYZED DIRECT ARYLATION; INTRAMOLECULAR DIRECT ARYLATION; H BOND ARYLATION; AZINE N-OXIDES; C-H; ROOM-TEMPERATURE; PALLADIUM; HETEROARENES; ACTIVATION; INDOLES;

D O I：

10.1021/ol902537d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient palladium-catalyzed synthesis of a range of substituted 2H-Indazoles via C-H arylation Is reported. Reactions are performed on water and provide a direct and mild route toward 2,3-diaryl indazoles of widespread biological significance.

引用

页码：224 / 226

页数：3

共 53 条

[1] Catalytic Direct Arylations in Polyethylene Glycol (PEG): Recyclable Palladium(0) Catalyst for C-H Bond Cleavages in the Presence of Air [J].

Ackermann, Lutz ;

Vicente, Ruben .

ORGANIC LETTERS, 2009, 11 (21) :4922-4925

[2] Palladium-Catalyzed Direct Arylations of Heteroarenes with Tosylates and Mesylates [J].

Ackermann, Lutz ;

Althammer, Andreas ;

Fenner, Sabine .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (01) :201-204

[3]

[Anonymous], ORG LETT

[4] Efficient palladium-catalyzed direct arylation of azines and diazines using ligand-free conditions [J].

Baso, Luca ;

Beccalli, Egle M. ;

Borsini, Elena ;

Broggini, Gianluigi .

TETRAHEDRON, 2009, 65 (17) :3486-3491

[5]

Cadogan J.I. G., 1968, ORG SYNTH, V48, P113, DOI DOI 10.15227/ORGSYN.048.0113

[6] Palladium-Catalyzed Domino Direct Arylation/N-Arylation: Convenient Synthesis of Phenanthridines [J].

Candito, David A. ;

Lautens, Mark .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (36) :6713-6716

[7] Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates [J].

Canivet, Jerome ;

Yamaguchi, Junichiro ;

Ban, Ikuya ;

Itami, Kenichiro .

ORGANIC LETTERS, 2009, 11 (08) :1733-1736

[8] Switching the Regioselectivity of Direct C-H Arylation of 1,3-Dimethyluracil [J].

Cernova, Miroslava ;

Pohl, Radek ;

Hocek, Michal .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 2009 (22) :3698-3701

[9] Organic Synthesis "On Water" [J].

Chanda, Arani ;

Fokin, Valery V. .

CHEMICAL REVIEWS, 2009, 109 (02) :725-748

[10] Palladium(II)-Catalyzed C-H Activation/C-C Cross-Coupling Reactions: Versatility and Practicality [J].

Chen, Xiao ;

Engle, Keary M. ;

Wang, Dong-Hui ;

Yu, Jin-Quan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (28) :5094-5115

← 1 2 3 4 5 6 →