Ca2+, pH and thermo triple-responsive mechanized Zr-based MOFs for on-command drug release in bone diseases

被引：157

作者：

Tan, Li-Li ^{[1
,2
]}

Song, Nan ^{[1
]}

Zhang, Sean Xiao-An ^{[2
]}

Li, Haiwei ^{[3
]}

Wang, Bo ^{[3
]}

Yang, Ying-Wei ^{[1
]}

机构：

[1] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Int Joint Res Lab Nanomicro Architecture Chem NMA, Coll Chem, Changchun 130012, Peoples R China

[2] Jilin Univ, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China

[3] Beijing Inst Technol, Sch Chem, Key Lab Cluster Sci, Minist Educ China, Beijing 100081, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2016年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC FRAMEWORKS; CANCER;

D O I：

10.1039/c5tb01789k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

We report a new approach towards the design of multi-stimuli responsive "gated scaffolds'' based on the combination of capped metal-organic frameworks (MOFs) and supramolecular[2]pseudorotaxanes. These mechanized Zr-MOFs showed negligible premature release, high drug encapsulation, low cytotoxicity and good biocompatibility. Around or inside the bone tumour cells, the pH, lysosomal pH, and osteoclast pH are observed to be lowered (acidosis), and thus the resulting osteolysis increases the Ca2+ concentration (hypercalcemia). The drug release from the mechanized MOFs was triggered by the simultaneous variations of pH and Ca2+ concentration in bone tumour cells. Hyperthermia (also called thermal therapy or thermotherapy) as a popular type of cancer treatment technique can also control drug release in the above-mentioned system. This design opens up the possibility of developing smart biomaterials for bone regeneration and cancer therapy.

引用

页码：135 / 140

页数：6

共 36 条

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