Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

被引：21

作者：

Bagwell, Claire L. ^{[1
]}

Moloney, Mark G. ^{[1
]}

Yaqoob, Muhammad ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

Antibacterials; Natural products; Click conjugation; DIASTEREOCONTROLLED SYNTHESIS; TETRAMIC ACIDS; DRUGS; CHEMISTRY; DISCOVERY; COMPOUND; PYROGLUTAMATES; BIOSYNTHESIS; CURROMYCIN; INHIBITOR;

D O I：

10.1016/j.bmcl.2010.02.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2090 / 2094

页数：5

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