Electrochemical study of oxygen interaction with lapachol and its radical anions

被引：42

作者：

Goulart, MOF

Falkowski, P

Ossowski, T

Liwo, A

机构：

[1] Univ Fed Alagaos, Dept Quim, BR-57072970 Alagoas, Brazil

[2] Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland

来源：

BIOELECTROCHEMISTRY | 2003年 / 59卷 / 1-2期

关键词：

lapachol; oxygen interactions; biological mechanism of action; oxidative stress;

D O I：

10.1016/S1567-5394(03)00005-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclovoltammetric studies were performed with lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone], in the absence and presence of oxygen, which aimed to investigate possible oxygen interaction with lapachol and its radical anion. The obtained results clearly indicate the consumption of the semiquinone anion-radicals by oxygen in an EC type reaction, generating the deprotonated form of lapachol and HOO.. The observed generation of reactive oxygen species (ROS) after electron transfer can be related to the mechanism of biological action of lapachol. (C) 2003 Elsevier Science B.V. All rights reserved.

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页码：85 / 87

页数：3

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