Imino-sugar-based nucleosides

被引：50

作者：

Schramm, VL

Tyler, PC

机构：

[1] Ind Res Ltd, Carbohydrate Chem, Lower Hutt, New Zealand

[2] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2003年 / 3卷 / 05期

关键词：

D O I：

10.2174/1568026033452465

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-C-nucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

引用

收藏

页码：525 / 540

页数：16

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