Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171

被引：68

作者：

Iwatsuki, Masato

Uchida, Ryuji

Takakusagi, Yoichi

Matsumoto, Atsuko

Jiang, Cheng-Lin

Takahashi, Yoko

Arai, Masayoshi

Kobayashi, Susumu

Matsumoto, Makoto

Inokoshi, Junji

Tomoda, Hiroshi

Omura, Satoshi

机构：

[1] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[3] Yunnan Univ, Inst Microbiol, Kunming 650091, Peoples R China

[4] Univ Tokyo, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

[5] Otsuka Pharmaceut Co Ltd, Microbiol Res Inst, Tokushima 7710192, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 06期

关键词：

lariatin A; lariatin B; lasso structure; anti-mycobacterial; peptide; tuberculosis; Rhodococcus jostii; soil aggregates;

D O I：

10.1038/ja.2007.48

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two anti-mycobacterial peptides with a lasso structure, named lariatins A and B, were separated by HP-20 and ODS column chromatographies and purified by HPLC from the culture broth of Rhodococcus jostii K01-B0171, which was isolated from soil aggregates collected in Yunnan, China. Lariains A and B showed growth inhibition against Mycobacterium smegmatis with MIC values of 3.13 and 6.25 mu g/ml in agar dilution method, respectively. Furthermore, lariatin A inhibited the growth of Mycobacterium tuberculosis with an MIC of 0.39 mu g/ml in liquid microdilution method.

引用

页码：357 / 363

页数：7

共 28 条

[1] Foreword from the co-editor-in-chief [J].