Palladium-Catalyzed Direct Benzylation of Azoles with Benzyl Carbonates

被引：123

作者：

Mukai, Tomoya ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

关键词：

CROSS-COUPLING REACTIONS; SITE-SELECTIVE SP(2); DIRECT ARYLATION; C-H; DIHYDROFOLATE-REDUCTASE; AROMATASE INHIBITORS; BOND FORMATION; BREAST-CANCER; O-XYLYLENES; ARYL;

D O I：

10.1021/ol1002576

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct aromatic Sp(2) C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently In the presence of a Pd-2(dba)(3)/dppp catalyst system and NaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic Sp(3) C-H benzylation with the second benzyl carbonates without employing any external base.

引用

页码：1360 / 1363

页数：4

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