MicroRNAs in the tumor endothelium: Novel controls on the angioregulatory switchboard

被引：55

作者：

Heusschen, Roy ^{[2
]}

van Gink, Matthijs ^{[3
]}

Griffioen, Arjan W. ^{[2
]}

Thijssen, Victor L. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Radiotherapy, Angiogenesis Lab, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Med Oncol, Angiogenesis Lab, NL-1081 HV Amsterdam, Netherlands

[3] Maastricht Univ, Med Ctr, Dept Pathol, Sch Oncol & Dev Biol, Maastricht, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2010年 / 1805卷 / 01期

关键词：

Cancer; Angiogenesis; miRNA; Endothelial cell; NITRIC-OXIDE SYNTHASE; IN-VIVO; VASCULAR INTEGRITY; ANGIOGENIC FACTORS; MOUSE DEVELOPMENT; CANCER; CELLS; EXPRESSION; TARGET; GROWTH;

D O I：

10.1016/j.bbcan.2009.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：87 / 96

页数：10

共 102 条

[1]

Molecular regulation of angiogenesis and lymphangiogenesis [J].

Adams, Ralf H. ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (06) :464-478

[2]

Clustering and conservation patterns of human microRNAs [J].

Altuvia, Y ;

Landgraf, P ;

Lithwick, G ;

Elefant, N ;

Pfeffer, S ;

Aravin, A ;

Brownstein, MJ ;

Tuschl, T ;

Margalit, H .

NUCLEIC ACIDS RESEARCH, 2005, 33 (08) :2697-2706

[3]

Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].

Asahara, T ;

Masuda, H ;

Takahashi, T ;

Kalka, C ;

Pastore, C ;

Silver, M ;

Kearne, M ;

Magner, M ;

Isner, JM .

CIRCULATION RESEARCH, 1999, 85 (03) :221-228

[4]

MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[5]

Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes [J].

Baskerville, S ;

Bartel, DP .

RNA, 2005, 11 (03) :241-247

[6]

Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[7]

MiRNAs in cancer: approaches, aetiology, diagnostics and therapy [J].

Blenkiron, Cherie ;

Miska, Eric A. .

HUMAN MOLECULAR GENETICS, 2007, 16 :R106-R113

[8]

MicroRNA-92a Controls Angiogenesis and Functional Recovery of Ischemic Tissues in Mice [J].

Bonauer, Angelika ;

Carmona, Guillaume ;

Iwasaki, Masayoshi ;

Mione, Marina ;

Koyanagi, Masamichi ;

Fischer, Ariane ;

Burchfield, Jana ;

Fox, Henrik ;

Doebele, Carmen ;

Ohtani, Kisho ;

Chavakis, Emmanouil ;

Potente, Michael ;

Tjwa, Marc ;

Urbich, Carmen ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

SCIENCE, 2009, 324 (5935) :1710-1713

[9]

Targeted gene-delivery strategies for angiostatic cancer treatment [J].

Brandwijk, Ricardo J. M. G. E. ;

Griffioen, Arjan W. ;

Thijssen, Victor L. J. L. .

TRENDS IN MOLECULAR MEDICINE, 2007, 13 (05) :200-209

[10]

Widespread translational inhibition by plant miRNAs and siRNAs [J].

Brodersen, Peter ;

Sakvarelidze-Achard, Lali ;

Bruun-Rasmussen, Marianne ;

Dunoyer, Patrice ;

Yamamoto, Yoshiharu Y. ;

Sieburth, Leslie ;

Voinnet, Olivier .

SCIENCE, 2008, 320 (5880) :1185-1190

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