Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation

被引：110

作者：

Ueda, Satoshi ^{[1
]}

Okada, Takahiro ^{[1
]}

Nagasawa, Hideko ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 14期

关键词：

2-(ALKYNYL)ARYL ISOCYANATES; INTRAMOLECULAR ARYLATION; OXIDATIVE ANNULATIONS; CYCLIZATION REACTION; SELECTIVE SYNTHESIS; KINASE INHIBITORS; CARBENE LIGANDS; BOND FORMATION; FUNCTIONALIZATION; ACTIVATION;

D O I：

10.1039/b926560k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A strategy involving palladium-catalysed aromatic C-H functionalisation/ intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl2MeCN2 and AgOCOCF3, a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield.

引用

页码：2462 / 2464

页数：3

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