Sensitive voltammetric determination of chloramphenicol by using single-wall carbon nanotube-gold nanoparticle-ionic liquid composite film modified glassy carbon electrodes

被引:142
作者
Xiao, Fei [1 ]
Zhao, Faqiong [1 ]
Li, Jiangwen [1 ]
Yan, Rui [1 ]
Yu, Jingjing [1 ]
Zeng, Baizhao [1 ]
机构
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
基金
中国国家自然科学基金;
关键词
chloramphenicol; ionic liquid; gold nanoparticles; single-wall carbon nanotubes; voltammetry;
D O I
10.1016/j.aca.2007.05.053
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A novel composite film modified glassy carbon electrode has been fabricated and characterized by scanning electron microscope (SEM) and voltammetry. The composite film comprises of single-wall carbon nanotube (SWNT), gold nanoparticle (GNP) and ionic liquid (i.e. 1-octyl-3-methylimidazolium hexafluorophosphate), thus has the characteristics of them. The resulting electrode shows good stability, high accumulation efficiency and strong promotion to electron transfer. On it, chloramphenicol can produce a sensitive cathodic peak at -0.66V (versus SCE) in pH 7.0 phosphate buffer solutions. Parameters influencing the voltammetric response of chloramphenicol are optimized, which include the composition of the film and the operation conditions. Under the optimized conditions, the peak current is linear to chloramphenicol concentration in the range of 1.0 x 10(-8)-6.0 x 10(-6) M, and the detection limit is estimated to be 5.0 x 10(-9) M after an accumulation for 150 s on open circuit. The electrode is applied to the determination of chloramphenicol in milk samples, and the recoveries for the standards added are 97.0% and 100.3%. In addition. the electrochemical reaction of chloramphenicol and the effect of single-wall carbon nanotube, gold nanoparticle and ionic liquid are discussed. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:79 / 85
页数:7
相关论文
共 25 条
[1]   Voltammetric determination of chloramphenicol in milk at electrochemically activated carbon fibre microelectrodes [J].
Agüí, L ;
Guzmán, A ;
Yáñez-Sedeño, P ;
Pingarrón, JM .
ANALYTICA CHIMICA ACTA, 2002, 461 (01) :65-73
[2]  
Bard A. J., 2001, ELECTROCHEMICAL METH, P211
[3]   Disposable electrochemical sensor for determination of nitroaromatic compounds by a single-run approach [J].
Chen, Jyh-Cheng ;
Shih, Jiun-Le ;
Liu, Chi-Ho ;
Kuo, Mei-Yueh ;
Zen, Jyh-Myng .
ANALYTICAL CHEMISTRY, 2006, 78 (11) :3752-3757
[4]   A surface plasmon resonance biosensor assay for the simultaneous determination of thiamphenicol, florefenicol, florefenicol amine and chloramphenicol residues in shrimps [J].
Dumont, V. ;
Huet, A. -C. ;
Traynor, I. ;
Elliott, C. ;
Delahaut, P. .
ANALYTICA CHIMICA ACTA, 2006, 567 (02) :179-183
[5]  
EPSTEIN RL, 1994, J AOAC INT, V77, P570
[6]   Strain differences in haematological response to chloroamphenicol succinate in mice: implications for toxicological research [J].
Festing, MFW ;
Diamanti, P ;
Turton, JA .
FOOD AND CHEMICAL TOXICOLOGY, 2001, 39 (04) :375-383
[7]  
Gomez Taylor B., 2006, J PHARMACEUT BIOMED, V41, P347
[8]   Direct electrochemical and electrocatalytic properties of heme protein immobilized on ionic liquid-clay-nanoparticle-composite films [J].
Hong Sun .
JOURNAL OF POROUS MATERIALS, 2006, 13 (3-4) :393-397
[9]   Metallic nanoparticle-carbon nanotube composites for electrochemical determination of explosive nitroaromatic compounds [J].
Hrapovic, Sabahudin ;
Majid, Ehsan ;
Liu, Yali ;
Male, Keith ;
Luong, John H. T. .
ANALYTICAL CHEMISTRY, 2006, 78 (15) :5504-5512
[10]  
Larner J, 1985, PHARMACOL BASIS THER, P7