A novel, one-pot, three-component synthesis of 4H-pyrido[1,2-a]pyrimidines

被引：19

作者：

Adib, Mehdi

Sayahi, Mohammad Hosein

Nosrati, Meisam

Zhu, Long-Guan

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 24期

关键词：

N-(2-pyridyl)amides; acetylenic esters; isocyanides; 4H-pyrido[1,2-a]pyrimidines; three-component synthesis;

D O I：

10.1016/j.tetlet.2007.04.068

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, one-pot, three-component synthesis of 4H-pyrido[1,2-a]pyrimidines is described. The reactive 1:1 zwitterionic intermediate, formed by the addition of isocyanides to dialkyl acetylenedicarboxylates, was trapped by N-(2-pyridyl)amides to produce the title compounds under mild reaction conditions in good yields. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4195 / 4198

页数：4

共 38 条

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