The role of small non-coding RNAs in genome stability and chromatin organization

被引：78

作者：

van Wolfswinkel, Josien C.

Ketting, Rene F. ^{[1
]}

机构：

[1] Hubrecht Inst KNAW, NL-3584 CT Utrecht, Netherlands

来源：

JOURNAL OF CELL SCIENCE | 2010年 / 123卷 / 11期

关键词：

Argonaute; Chromatin; Germ cell; Methylation; piRNA; siRNA; DIRECTED DNA-METHYLATION; H3; LYSINE-9; METHYLATION; DOUBLE-STRANDED-RNA; SEX-CHROMOSOME INACTIVATION; DROSOPHILA-MELANOGASTER GERMLINE; YEAST SCHIZOSACCHAROMYCES-POMBE; DE-NOVO METHYLATION; DICER-LIKE PROTEIN; HUMAN X-CHROMOSOME; C-ELEGANS;

D O I：

10.1242/jcs.061713

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Small non-coding RNAs make up much of the RNA content of a cell and have the potential to regulate gene expression on many different levels. Initial discoveries in the 1990s and early 21st century focused on determining mechanisms of post-transcriptional regulation mediated by small-interfering RNAs (siRNAs) and microRNAs (miRNAs). More recent research, however, has identified new classes of RNAs and new regulatory mechanisms, expanding the known regulatory potential of small non-coding RNAs to encompass chromatin regulation. In this Commentary, we provide an overview of these chromatin-related mechanisms and speculate on the extent to which they are conserved among eukaryotes.

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收藏

页码：1825 / 1839

页数：15

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