A Highly Selective FRET-Based Fluorescent Probe for Detection of Cysteine and Homocysteine

被引：113

作者：

Shiu, Hoi-Yan ^{[2
,3
]}

Chong, Hiu-Chi ^{[1
]}

Leung, Yun-Chung ^{[1
]}

Wong, Man-Kin ^{[1
]}

Che, Chi-Ming ^{[2
,3
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Chem, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

[3] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 11期

关键词：

bioimaging; fluorescence; FRET; quenchers; thiols; PERFORMANCE LIQUID-CHROMATOGRAPHY; CYCLOMETALATED PLATINUM(II) COMPLEXES; MOLECULAR-MASS THIOLS; CAPILLARY-ELECTROPHORESIS; PROTEIN-BINDING; AQUEOUS-MEDIUM; HUMAN PLASMA; HUMAN BLOOD; GLUTATHIONE; FLUOROPHORE;

D O I：

10.1002/chem.200903121

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorescent probe: A "turn-on" FRET-based fluorescent probe for selective detection of cysteine (Cys) and homocysteine (Hey) under physiological conditions was synthesised (see figure). The probe features excellent selectivity, fast response times and good linearity towards Cys and Hey detection © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3308 / 3313

页数：6

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