Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

被引：77

作者：

Lee, Ho-Man ^{[1
,2
]}

Chan, Daniel Shiu-Hin ^{[1
,2
]}

Yang, Fang ^{[1
,2
]}

Lam, Ho-Yu ^{[1
,2
]}

Yan, Siu-Cheong ^{[1
,2
]}

Che, Chi-Ming ^{[1
,2
]}

Ma, Dik-Lung ^{[1
,2
,3
]}

Leung, Chung-Hang ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China

[3] Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 26期

关键词：

HUMAN TELOMERIC DNA; ASPERGILLUS-FONSECAEUS; PROMOTER REGION; SMALL-MOLECULE; ONCOGENE EXPRESSION; DOWN-REGULATION; DRUG DISCOVERY; KIT ONCOGENE; BINDING; TRANSCRIPTION;

D O I：

10.1039/b926359d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

引用

收藏

页码：4680 / 4682

页数：3

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