Enantioselective Alkenylation via Nickel-Catalyzed Cross-Coupling with Organozirconium Reagents

被引：123

作者：

Lou, Sha ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 14期

基金：

美国国家卫生研究院;

关键词：

RACEMIC ALPHA-BROMOKETONES; SECONDARY ALKYL-HALIDES; ARYLZINC REAGENTS; VINYLATION; ELECTROPHILES;

D O I：

10.1021/ja1017046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new family of organometallic compounds, organozirconium reagents, are shown to serve as suitable partners in cross-coupling reactions of (activated) secondary alkyl electrophiles. Thus, the first catalytic method for coupling secondary alpha-bromoketones with alkenylmetal reagents has been developed, specifically, a mild, versatile, and stereoconvergent carbon-carbon bond-forming process that generates potentially labile beta,gamma-unsaturated ketones with good enantioselectivity.

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页码：5010 / +

页数：3

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