Snap-Top Nanocarriers

被引：93

作者：

Ambrogio, Michael W. ^{[3
,4
]}

Pecorelli, Travis A. ^{[1
,2
]}

Patel, Kaushik ^{[3
,4
]}

Khashab, Niveen M. ^{[3
,4
]}

Trabolsi, All ^{[3
,4
]}

Khatib, Hussam A. ^{[3
,4
]}

Botros, Youssry Y. ^{[3
,4
,5
,6
]}

Zink, Jeffrey I. ^{[1
,2
]}

Stoddarrt, J. Fraser ^{[3
,4
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA

[3] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[5] Intel Labs, Santa Clara, CA 95054 USA

[6] KACST, Natl Ctr Nano Technol Res, Riyadh 11442, Saudi Arabia

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

OPERATED MECHANIZED NANOPARTICLES; RELEASE DRUG-DELIVERY; MESOPOROUS SILICA; MOLECULAR RECOGNITION; THIN-FILMS; GLUTATHIONE; NANOVALVES; CUCURBITURIL; FUNCTIONALIZATION; NANOCONTAINERS;

D O I：

10.1021/ol101286a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,- which are encircled by cucurbit[6]uril or alpha-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.

引用

页码：3304 / 3307

页数：4

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