Photolabile linker for the solid-phase synthesis of base-sensitive oligonucleotides

被引：37

作者：

DellAquila, C ^{[1
]}

Imbach, JL ^{[1
]}

Rayner, B ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CNRS,CHIM BIOORGAN LAB,F-34095 MONTPELLIER 5,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(97)01154-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Nitrophenyl-1,3-propanediol was covalently linked to long chain alkyl amine controlled pore glass (LCAA-CPG) beads through a stable phosphoramidate diester link. The resulting solid support was found suitable for the automated synthesis of 3'-phosphate unmodified as well as base-sensitive oligonucleotides. Efficient cleavage from the solid support was achieved by photolysis. (C) 1997 Elsevier Science Ltd.

引用

页码：5289 / 5292

页数：4

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