Modeling Development and Disease with Organoids

被引：2394

作者：

Clevers, Hans ^{[1
,2
]}

机构：

[1] Royal Netherlands Acad Arts & Sci, Princess Maxima Ctr, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands

来源：

CELL | 2016年 / 165卷 / 07期

关键词：

PLURIPOTENT STEM-CELLS; IN-VITRO EXPANSION; DUCTAL PANCREATIC-CANCER; EPITHELIAL-CELLS; CYSTIC-FIBROSIS; SMALL-INTESTINE; DIRECTED DIFFERENTIATION; ALVEOLAR CELLS; MAMMARY-GLAND; SINGLE LGR5;

D O I：

10.1016/j.cell.2016.05.082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key structural and functional properties of organs such as kidney, lung, gut, brain and retina. Organoid technology can therefore be used to model human organ development and various human pathologies 'n a dish.'' Additionally, patient-derived organoids hold promise to predict drug response in a personalized fashion. Organoids open up new avenues for regenerative medicine and, in combination with editing technology, for gene therapy. The many potential applications of this technology are only beginning to be explored.

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页码：1586 / 1597

页数：12

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