Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts

被引:97
作者
Lee, D [1 ]
Huh, EA [1 ]
Kim, MJ [1 ]
Jung, HM [1 ]
Koh, JH [1 ]
Park, J [1 ]
机构
[1] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, Kyungbuk, South Korea
关键词
D O I
10.1021/ol006159y
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] An enzyme-metal combo reaction has been developed for the dynamic kinetic resolution of allylic alcohols in which racemic substrates are transformed by a lipase and a ruthenium complex in the presence of an acyl donor to allylic acetates of high optical purity in over 80% yield.
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页码:2377 / 2379
页数:3
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