Regioselective substitution of fluorine in F8BINOL as a versatile route to new ligands with axial chirality

被引：43

作者：

Chen, Y ^{[1
]}

Yekta, S ^{[1
]}

Martyn, LJP ^{[1
]}

Zheng, J ^{[1
]}

Yudin, AK ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 22期

关键词：

D O I：

10.1021/ol006428k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Nucleophilic substitution of aromatic fluorine in F8BINOL offers the possibility of selectively introducing a variety of substituents at the 6, 6', 7, and 7' positions. The configurational integrity of the homochiral precursors is maintained under the conditions described, allowing one to carry out these modification protocols on a microscale without the need for subsequent resolution steps. The resulting chiral ligands have been investigated as precursors to new asymmetric catalysts.

引用

页码：3433 / 3436

页数：4

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