Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

被引：168

作者：

Sans, Victor ^{[1
]}

Cronin, Leroy ^{[2
]}

机构：

[1] Univ Nottingham, Dept Chem & Environm Engn, Nottingham NG7 2RD, England

[2] Univ Glasgow, Sch Chem, WestChem, Glasgow G12 8QQ, Lanark, Scotland

来源：

CHEMICAL SOCIETY REVIEWS | 2016年 / 45卷 / 08期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

NMR-SPECTROSCOPY; RAMAN-SPECTROSCOPY; CHEMICAL-SYNTHESIS; MASS-SPECTROMETRY; ORGANIC-SYNTHESIS; CHEMISTRY; PLATFORM; SYSTEMS; NANOPARTICLES; INTELLIGENT;

D O I：

10.1039/c5cs00793c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.

引用

页码：2032 / 2043

页数：12

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