Genetic linkage and association analyses for trait mapping in Plasmodium falciparum

被引：64

作者：

Su, Xinzhuan ^{[1
]}

Hayton, Karen ^{[1
]}

Wellems, Thomas E. ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 07期

关键词：

D O I：

10.1038/nrg2126

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic studies of Plasmodium falciparum laboratory crosses and field isolates have produced valuable insights into determinants of drug responses, antigenic variation, disease virulence, cellular development and population structures of these virulent human malaria parasites. Full-genome sequences and high-resolution haplotype maps of SNPs and microsatellites are now available for all 14 parasite chromosomes. Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease.

引用

页码：497 / 506

页数：10

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