Polarizability of G4-DNA observed by electrostatic force microscopy measurements

被引：69

作者：

Cohen, Hezy

Sapir, Tomer

Borovok, Natalia

Molotsky, Tatiana

Di Felice, Rosa

Kotlyar, Alexander B.

Porath, Danny ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Phys Chem, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

[3] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Biochem, IL-69978 Ramat Gan, Israel

[4] Tel Aviv Univ, Nanotechnol Ctr, IL-69978 Ramat Gan, Israel

[5] CNR, INFM, Natl Ctr Nanostruct & Biosyst Surfaces S3, I-41100 Modena, Italy

来源：

NANO LETTERS | 2007年 / 7卷 / 04期

关键词：

D O I：

10.1021/nl070013b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

G4-DNA, a quadruple helical motif of stacked guanine tetrads, is stiffer and more resistant to surface forces than double-stranded DNA (dsDNA), yet it enables self-assembly. Therefore, it is more likely to enable charge transport upon deposition on hard supports. We report clear evidence of polarizability of long G4-DNA molecules measured by electrostatic force microscopy, while coadsorbed dsDNA molecules on mica are electrically silent. This is another sign that G4-DNA is potentially better than dsDNA as a conducting molecular wire.

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收藏

页码：981 / 986

页数：6

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