Development of practical rhodium phosphine catalysts for the hydrogenation of β-dehydroamino acid derivatives

被引：35

作者：

Enthaler, Stephan

Erre, Giulia

Junge, Kathrin

Holz, Jens

Boerner, Armin

Alberico, Elisabetta

Nieddu, Ilenia

Gladiali, Serafino

Beller, Matthias

机构：

[1] Univ Rostock eV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

[2] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[3] CNR, Ist Chim Biomol, I-07040 Sassari, Italy

[4] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2007年 / 11卷 / 03期

关键词：

D O I：

10.1021/op0602270

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The rhodium-catalyzed asymmetric hydrogenation of various, beta-dehydroamino acid derivatives to give optically active,beta-amino acids has been examined. Chiral monodentate 4,5-dihydro-3H-dinaphthophosphepines, which are easily tuned and accessible in a multi-10-g scale, have been used as ligands. The enantioselectivity is largely dependent on the nature of the substituent at the phosphorous atom and on the structure of the substrate. Applying optimized conditions up to 94% ee was achieved.

引用

页码：568 / 577

页数：10

共 103 条

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