Asymmetric synthesis of 3-substituted isoindolinones: Application to the total synthesis of (+)-lennoxamine

被引：173

作者：

Comins, DL ^{[1
]}

Schilling, S ^{[1
]}

Zhang, YC ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/ol047824w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An anionic chiral auxiliary mediated asymmetric alkylation of carbamate 2 provides 3-substituted isoindolinones 4 in high ee. This methodology was used in the first asymmetric synthesis of (+)-lennoxamine.

引用

页码：95 / 98

页数：4

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