Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice

被引：88

作者：

Olivera, Ana ^{[1
]}

Eisner, Christoph ^{[2
]}

Kitamura, Yoshiaki ^{[1
]}

Dillahunt, Sandra ^{[1
]}

Allende, Laura ^{[3
]}

Tuymetova, Galina ^{[3
]}

Watford, Wendy ^{[4
]}

Meylan, Francoise ^{[5
]}

Diesner, Susanne C. ^{[1
]}

Li, Lingli ^{[2
]}

Schnermann, Jurgen ^{[2
]}

Proia, Richard L. ^{[3
]}

Rivera, Juan ^{[1
]}

机构：

[1] Natl Inst Arthrit & Musculoskeletal & Skin Dis NI, Immunogenet Mol Lab, NIH, Bethesda, MD USA

[2] NIDDK, Kidney Dis Branch, NIH, Bethesda, MD USA

[3] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD USA

[4] NIAMS, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD USA

[5] NIAMS, Autoimmun Branch, NIH, Bethesda, MD USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 05期

基金：

美国国家科学基金会;

关键词：

MAST-CELL DEGRANULATION; FC-EPSILON-RI; VASCULAR-PERMEABILITY; SYSTEMIC-ANAPHYLAXIS; S1P(1) RECEPTOR; GAMMA RIII; HISTAMINE; ACTIVATION; EXPRESSION; IMMUNE;

D O I：

10.1172/JCI40659

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sphingosine kinase 1 (SphK1) and SphK2 are ubiquitous enzymes that generate sphingosine-1-phosphate (SIP), a ligand for a family of G protein-coupled receptors (S1PR1-S1PR5) with important functions in the vascular and immune systems. Here we explore the role of these kinases and receptors in recovery from anaphylaxis in mice. We found that Sphk2(-/-) mice had a rapid recovery from anaphylaxis. In contrast, Sphk1(-/-) mice showed poor recovery from anaphylaxis and delayed histamine clearance. Injection of SIP into Sphk1(-/-) mice increased histamine clearance and promoted recovery from anaphylaxis. Adoptive cell transfer experiments demonstrated that SphK1 activity was required in both the hematopoietic and nonhematopoietic compartments for recovery from anaphylaxis. Mice lacking the SW receptor S1PR2 also showed a delay in plasma histamine clearance and a poor recovery from anaphylaxis. However, SW did not promote the recovery of S1pr2(-/-) mice from anaphylaxis, whereas S1pr2(+/-) mice showed partial recovery. Unlike Sphk2(-/-) mice, Sphk1(-/-) and S1pr2(-/-) mice had severe hypotension during anaphylaxis. Thus, SphK1-produced S1P regulates blood pressure, histamine clearance, and recovery from anaphylaxis in a manner that involves S1PR2. This suggests that specific S1PR2 agonists may serve to counteract the vasodilation associated with anaphylactic shock.

引用

页码：1429 / 1440

页数：12

共 61 条

[51] Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN [J].

Sanchez, Teresa ;

Skoura, Athanasia ;

Wu, Ming Tao ;

Casserly, Brian ;

Harrington, Elizabeth O. ;

Hla, Timothy .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (06) :1312-1318

[52] ACTIONS AND METABOLISM OF HISTAMINE IN GLOMERULI AND TUBULES OF THE HUMAN-KIDNEY [J].

SEDOR, JR ;

ABBOUD, HE .

KIDNEY INTERNATIONAL, 1984, 26 (02) :144-152

[53] Adrenaline for the treatment of anaphylaxis: cochrane systematic review [J].

Sheikh, A. ;

Shehata, Y. A. ;

Brown, S. G. A. ;

Simons, F. E. R. .

ALLERGY, 2009, 64 (02) :204-212

[54] Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and α-actinin [J].

Singleton, PA ;

Dudek, SM ;

Chiang, ET ;

Garcia, JGN .

FASEB JOURNAL, 2005, 19 (12) :1646-1656

[55] Regulation of vascular physiology and pathology by the S1P2 receptor subtype [J].

Skoura, Athanasia ;

Hla, Timothy .

CARDIOVASCULAR RESEARCH, 2009, 82 (02) :221-228

[56] Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice [J].

Sumi, Tamaki ;

Fukushima, Atsuki ;

Nishino, Koji ;

Fukuda, Ken ;

Kumagai, Naoki ;

Nishida, Teruo ;

Ueno, Hisayuki .

CELL BIOLOGY INTERNATIONAL, 2009, 33 (04) :534-541

[57] Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells [J].

Tauseef, Mohammad ;

Kini, Vidisha ;

Knezevic, Nebojsa ;

Brannan, Melissa ;

Ramchandaran, Ram ;

Fyrst, Henrik ;

Saba, Julie ;

Vogel, Stephen M. ;

Malik, Asrar B. ;

Mehta, Dolly .

CIRCULATION RESEARCH, 2008, 103 (10) :1164-U214

[58] High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes [J].

Toubanaki, Dimitra K. ;

Christopoulos, Theodore K. ;

Ioannou, Penelope C. ;

Flordellis, Christodoulos S. .

ANALYTICAL BIOCHEMISTRY, 2009, 385 (01) :34-41

[59] Early activation of sphingosine kinase in mast cells and recruitment to FcεRI are mediated by its interaction with Lyn kinase [J].

Urtz, N ;

Olivera, A ;

Bofill-Cardona, E ;

Csonga, R ;

Billich, A ;

Mechtcheriakova, D ;

Bornancin, F ;

Woisetschlager, M ;

Rivera, J ;

Baumruker, T .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (19) :8765-8777

[60] Vascular endothelium as a contributor of plasma sphingosine 1-phosphate [J].

Venkataraman, Krishnan ;

Lee, Yong-Moon ;

Michaud, Jason ;

Thangada, Shobha ;

Ai, Youxi ;

Bonkovsky, Herbert L. ;

Parikh, Nehal S. ;

Habrukowich, Cheryl ;

Hla, Timothy .

CIRCULATION RESEARCH, 2008, 102 (06) :669-676

← 1 2 3 4 5 6 7 →