Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus

被引：291

作者：

Glinka, A ^{[1
]}

Wu, W ^{[1
]}

Onichtchouk, D ^{[1
]}

Blumenstock, C ^{[1
]}

Niehrs, C ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM, DIV MOL EMBRYOL, D-69120 HEIDELBERG, GERMANY

来源：

NATURE | 1997年 / 389卷 / 6650期

关键词：

D O I：

10.1038/39092

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Spemann organizer of the amphibian embryo can be subdivided into two discrete activities, namely trunk organizer and head organizer(1). Several factors secreted from the organizer that are involved in trunk organization are thought to act by repressing Bmp signalling(2-4). With the exception of the secreted factor cerberus(5), little is known about head-organizer inducers, Here we show that co-expression of a dominant-negative Bmp receptor with inhibitors of the Wnt-signalling pathway in Xenopus leads to the induction of complete secondary axes, including a head, This induction does not require expression of the siamois marker of Nieuwkoop centre signalling, suggesting that cells are directly shifting to head-organizer fate, Furthermore, we fmd that cerberus is a potent inhibitor of Wnt signalling, Our results indicate that head-organizer activity results from the simultaneous repression of Bmp and Wnt signalling and they suggest a mechanism for region-specific induction by the organizer.

引用

页码：517 / 519

页数：3

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