A general modular method of azaindole and thienopyrrole synthesis via Pd-catalyzed tandem couplings of gem-dichloroolefins

被引：92

作者：

Fang, Yuan-Qing ^{[1
]}

Yuen, Josephine ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Chem Labs, Toronto, ON M5S 3H6, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 14期

关键词：

ONE-POT SYNTHESIS; BOND FORMATION; RWJ; 68354; DERIVATIVES; INDOLE; 7-AZAINDOLES; 6-AZAINDOLES; INHIBITOR; BINDING; AMINOPYRIDINES;

D O I：

10.1021/jo070460b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed reaction of gem-dichloroolefins and a boronic acid via a tandem intramolecular C-N and intermolecular Suzuki coupling process gave corresponding substituted azaindoles or thienopyrroles. This method is a very modular protocol to synthesize all four isomers of azaindole and two isomers of thienopyrroles in good to excellent yield.

引用

页码：5152 / 5160

页数：9

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