AUTOMATED SAMPLE PREPARATION BY ONLINE DIALYSIS AND TRACE ENRICHMENT - ANALYSIS OF MORPHINE, 6-MONOACETYLMORPHINE, CODEINE, ETHYLMORPHINE AND PHOLCODINE IN PLASMA AND WHOLE-BLOOD BY CAPILLARY GAS-CHROMATOGRAPHY AND CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：27

作者：

KROGH, M

CHRISTOPHERSEN, AS

RASMUSSEN, KE

机构：

[1] NATL INST FORENS TOXICOL,N-0320 OSLO,NORWAY

[2] UNIV OSLO,INST PHARM,N-0316 OSLO,NORWAY

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 621卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80074-E

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A fully automated sample preparation method for the determination of five opiates in human plasma and whole blood is described. The technique combines dialysis and trace enrichment prior to gas chromatography and gas chromatography-mass spectrometry. Dialysis and trace enrichment on a polymer column was shown to be a highly reliable method for sample preparation. The method can be used, after minor modification, to determine other basic drugs in plasma and whole blood. The method demonstrates the potential of the automated sequential trace enrichment of dialysate (ASTED) system for automated sample preparation.

引用

页码：41 / 48

页数：8

共 7 条

[1] ONLINE COMBINATION OF DIALYSIS AND COLUMN-SWITCHING LIQUID-CHROMATOGRAPHY AS A FULLY AUTOMATED SAMPLE PREPARATION TECHNIQUE FOR BIOLOGICAL SAMPLES - DETERMINATION OF NITROFURAN RESIDUES IN EDIBLE PRODUCTS [J].