We have investigated the 1/f noise of n- and p-channel MOS transistors through irradiation and biased anneals. While the increase in noise during irradiation is similar for both types of devices, the noise differs significantly in response to biased anneals. In particular, the noise decreases with decreasing DELTA-V(ot) during positive-bias anneals in nMOS transistors but increases during positive-bias anneals for pMOS transistors. Conversely, negative bias anneals increase the noise in nMOS devices but decrease the noise in pMOS devices. These results are explained in terms of majority carrier trapping and de-trapping at oxide defects near the Si/SiO2 interface. Under normal operating bias conditions (positive bias for nMOS and negative bias for pMOS), the 1/f noise of both n- and p-channel transistors decreases through post-irradiation annealing.